Why Do CNV and Expression Profile Integration Analysis?

There is some correlation between changes in expression values and copy number variation (CNV) regions for many genes in cancer. Integrating these two levels of data can uncover the DNA-level changes behind the expression changes of specific genes in cancer. Integrated analysis of gene copy number and expression profiles is widely used in medicine to summarize the patterns of gene copy number changes and expression profiles to predict changes in clinical indicators of cancer. The main applications are as follows: 1) Mining the causes of gene expression changes in disease that may be due to copy number variations (CNV) of genes on the genome. 2) To uncover pathogenic pathways that are significantly enriched in copy number variations (CNV) of genes in diseases, and to screen specific key pathways for diseases (cancer). 3) Apply CNV-driven genes as parameters of Cox risk model to predict patient survival time. 4) Association analysis of gene copy number abnormalities to mine new gene binding sites for cancer.

Our Integrative Analysis Services of CNV and Expression Profile

Creative Proteomics provides you with integrative analysis services of CNV and expression profile, seamlessly connecting your experiments to provide powerful insights into the evidence of complex life activity mechanisms.

• Expression Profile
• Whole Genomic Sequencing

Bioinformatics Analysis

1. Data matching of CNV data and gene expression profiles.
2. Individual primary screening of CNV regions for each sample.
3. Screening CNV regions for disease and normal group samples and obtaining genes within CNV regions.
4. Pre-process gene expression profiles and screen for differential genes in the disease vs. normal group.
5. Obtain overlapping genes in the CNV region and differential genes.

Data Source

• Sequencing data or microarray data

Delivery Content

Creative Proteomics will provide you with a detailed report, including graphs obtained from the integrated analysis and related analysis software and parameters used. In addition, the raw sequencing data will be delivered to you as well.

Our Advantages

• Scientific program design, strict quality control management
• Rich project experience, high quality project service
• Advanced technology platform, high-end equipment, scientific management
• Powerful analytical capabilities
• Customized analysis mode

Creative Proteomics relies on advanced platforms and cutting-edge technologies to provide omics services to customers around the world, and provide accurate and detailed analysis reports. In addition, we also provide multi-omics integrated analysis services. If you want to know more, please contact us, Creative Proteomics can be trusted.