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Integrative Analysis of PTMs Proteomics and Targeted Metabolomics

Based on the advanced technology platform, Creative Proteomics provides PTMs proteomics and targeted metabolomics services and integrated analysis services of PTMs proteomics-targeted metabolomics. We can provide you with a one-stop service from experimental design, sample detection, independent omics data analysis to integrative analysis to meet a variety of research needs.

Why Do Integrative Analysis of PTMs Proteomics and Targeted Metabolomics?

Various modifications such as acetylation, phosphorylation, and ubiquitination are key mechanisms of metabolic regulation, which not only indirectly regulate the expression of metabolic genes by modifying transcription factors, but also directly regulate metabolic flux by modifying metabolic enzymes. Therefore, modification has become the most important direction of metabolic mechanism research, and targeted metabolomics and PTMs proteomics are the most effective research methods to connect phenotype and mechanism.

Our Integrative Analysis Services of PTMs Proteomics and Targeted Metabolomics

In the integrated analysis, we will focus on the three key factors of expression pattern, biological function, and regulatory mechanism, and analyze the following scientific issues: (1) Compare the similarities and differences of expression patterns of protein post-translational modifications and metabolites, reveal the similarities and differences of its changing trends at different levels after biological treatment. (2) Screen the important pathways that differentially modified proteins and differential metabolites are involved in, and reveal their potential functions in related biological changes. (3) Analyze the regulatory relationship between protein post-translational modifications and metabolites, and describe the potential regulatory mechanism between protein post-translational modifications and metabolites.

Bioinformatics Analysis

Analyze content Details
Expression pattern analysis PCA analysis of modified proteome and targeted metabolome.
Metabolic pathways integrative analysis of PTMs proteomics and targeted metabolomics Comparative analysis of KEGG metabolic pathway annotations
Comparative analysis of KEGG pathway enrichment
Differential expression profiles of KEGG-enriched pathways
KEGG pathway visualization
Regulatory relationship analysis between modified proteomes and targeted metabolites Correlation analysis
Correlation coefficient matrix heatmap
Correlation coefficient hierarchical clustering heatmap
Correlation coefficient regulation network analysis
Regulatory relationship analysis between PTMs proteomics and targeted metabolomics Multivariate statistical integration analysis (O2PLS correlation analysis, OPLS related variable screening)

Delivery Content

Creative Proteomics will provide you with a detailed report, including:

  • Related analysis software and parameters used
  • Graphs obtained from the integrated analysis

Why Choose Us?

  • Upgraded instrument platform. We use advanced mass spectrometers to improve the accuracy of quantification, the depth of identification, and the number of identifications.
  • Professional bioinformatics analysis. Creative Proteomics has a strong bioinformatics team, which can meet various in-depth data analysis needs of customers, and can also provide integrated analysis services with other omics.
  • One-stop service. Customers only need to provide samples, and Creative Proteomics will complete the full-service process from sample preparation, library preparation, sequencing / Mass detection to bioinformatics analysis, as well as integrated analysis of multi-omics.
  • Tailored and personalized analysis content is available for special projects.

Creative Proteomics relies on advanced platforms and cutting-edge technologies to provide omics services to customers around the world, and provide accurate and detailed analysis reports. In addition, we also provide multi-omics integrated analysis services. You can discuss with our technical engineers to customize solutions or build new methods to meet your specific needs. If you have any questions, you can tell us through the inquiry form, and our technicians will communicate with you. Please don't hesitate to contact us, Creative Proteomics can be trusted.

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Welcome to Consult

Creative Proteomics, your unparalleled center of excellence in sequencing, mass spectrometry, and bioinformatics analysis platforms, is elevating the landscape of research. Our seamless integration of these cutting-edge capabilities ensures that clients receive extraordinary multi-omics joint analysis services.

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