Why Do scRNA-seq and Metabolomics Integrative Analysis?

The transcriptome of a sample or tissue is the average of the expression of one transcriptome of all cells, which does not reflect the state of all cells or a certain group of cells in the sample, so RNA-seq technology is needed for in-depth study of the transcriptional state of a single cell or a group of cells, which will reflect the state of the tissue more finely and accurately. The metabolome is downstream of the gene regulatory network, displaying the terminal information of the central law.

The integrated analysis of scRNA-seq and metabolomics can bridge the upstream and downstream of the gene regulatory network and provide multi-omics and multi-level insights to resolve cellular metabolic heterogeneity. We aim to provide cutting-edge, accurate, and high-quality data and analysis results for tumor microenvironment, immune microenvironment research, developmental biology, and other research.

Our Integrative Analysis Services of scRNA-seq and Metabolomics

Creative Proteomics has an end-to-end single-cell sequencing system that provides a full-flow solution from tissue sample processing to data analysis and mining. It also has a total solution for high-quality metabolomics detection and analysis. Combining leading scRNA-seq and high quality metabolomics technologies, we bridge the entire process of upstream and downstream multi-omics research and data analysis in order to provide scientists with cutting-edge, accurate, high quality data and analysis results. We are committed to applying breakthrough integrated multi-omics analysis technologies to clinical testing, health management and drug development.

• Single-cell Omics and Spatial Omics
• scRNA-seq
• Untargeted Metabolomics

Bioinformatics Analysis

• Cellular profiling
  Analysis of cell type composition and percentage of different samples, (combined with single cell immunomic library to analyze TCR/BCR clonal diversity).
• Transcription factor regulatory network analysis
  Analysis of transcriptional regulatory mechanisms of metabolism-related genes in key cell types.
• Cell trajectory analysis
  Analysis of the proposed temporal sequence of cells within cell subpopulations to infer cell differentiation process or metastasis status.
• Metabolic analysis
  Metabolite quantification, differential metabolite (biomarker) screening.
• Metabolome and single cell association analysis
  Metabolic gene association analysis to infer metabolic heterogeneity of cellular subpopulations.
  Response of different cells to metabolic profiles to elucidate disease mechanisms at the cellular level.

Sample Requirements

• ScRNA-seq samples are required to refer to specific scRNA-seq products
• Metabolomics samples are required to refer to specific metabolomics products
• Note: When sending samples, scRNA-seq samples and metabolomics samples should be mixed and sent separately.

Delivery Content

Creative Proteomics will provide you with a detailed report, including:

• Graphs obtained from the integrated analysis
• Related analysis software and parameters used.

In addition, the raw sequencing data will be delivered to you as well.

Our Advantages

• High-end equipment and scientific management to overcome the extraction and detection of difficult samples.
• Scientific protocol design, strict quality control management
• Powerful analysis capability, customized analysis mode
• Rich project experience, high quality project service

Creative Proteomics relies on advanced platforms and cutting-edge technologies to provide omics services to customers around the world, and provide accurate and detailed analysis reports. In addition, we also provide multi-omics integrated analysis services. If you want to know more, please contact us, Creative Proteomics can be trusted.