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Integrative Analysis of scRNA-seq and Spatial Transcriptomics

Based on the advanced technology platform, Creative Proteomics provides single-cell transcriptomics sequencing (scRNA-seq) and spatial transcriptomics sequencing services, and offers integration analysis of scRNA-seq and spatial transcriptomics. We can provide one-stop service from experimental design, sample detection, independent omics data analysis to integration analysis to meet various research needs.

Why Do scRNA-seq and Spatial Transcriptomics Integrative Analysis?

Single-cell sequencing technology can perform cell type identification well and reveal tissue heterogeneity, but due to the enzymatic digestion of tissues when obtaining cell suspensions, resulting in the loss of tissue spatial location information. In contrast, spatial transcriptomics avoids the loss of cell location information in tissues and can provide both spatial location information and gene expression information, but the unit of detection is not a single cell.

Combining these two techniques and integrating the analysis of scRNA-seq and spatial transcriptomics allows both spatial localization and precise cell type annotation, thus revealing cellular interactions more precisely. Their integrated analysis has been widely used in tumor microenvironment, immune system, embryonic development, pharmacodynamic studies, etc.

Our Integrative Analysis Services of scRNA-seq and Spatial Transcriptomics

Creative Proteomics provides you with integrative analysis services of scRNA-seq and spatial transcriptomics, seamlessly connecting your experiments to provide powerful insights into the molecular mechanisms of complex life activity phenomena.

Bioinformatics Analysis Ideas

1. Spatial mapping - the distribution of cells in tissue space is the starting point and foundation of association analysis.

  • Correlation analysis
  • Spot cell composition analysis
  • Cell distribution mapping

2. Spatial heterogeneity - the molecular expression characteristics of the same cell type in different tissue regions.

  • Cellular region up-regulated genes
  • Enrichment analysis

3. Core genes - which genes expressed in which cells of which tissues cause phenotypic changes.

  • Up-regulated genes in regional cells
  • Core genes
  • Enrichment analysis

Note: There is not only an analysis idea. If you want to know more, please contact us and consult our technical engineers.

Sample Requirements

  • scRNA-seq samples are required to refer to specific scRNA-seq products
  • Spatial transcriptomics sequencing samples are required to refer to specific spatial transcriptomics products
  • Note: scRNA-seq sequencing samples and spatial transcriptomics sequencing samples should be mixed and sent separately.

Delivery Content

Creative Proteomics will provide you with a detailed report, including:

  • Graphs obtained from the integrated analysis
  • Related analysis software and parameters used.

In addition, the raw sequencing data will be delivered to you as well.

Our Advantages

  • High-end equipment and scientific management to overcome the extraction and detection of difficult samples.
  • Scientific protocol design, strict quality control management
  • Powerful analysis capability, customized analysis mode
  • Rich project experience, high quality project service

Creative Proteomics relies on advanced platforms and cutting-edge technologies to provide omics services to customers around the world, and provide accurate and detailed analysis reports. In addition, we also provide multi-omics integrated analysis services. If you want to know more, please contact us, Creative Proteomics can be trusted.

For Research Use Only.

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Welcome to Consult

Creative Proteomics, your unparalleled center of excellence in sequencing, mass spectrometry, and bioinformatics analysis platforms, is elevating the landscape of research. Our seamless integration of these cutting-edge capabilities ensures that clients receive extraordinary multi-omics joint analysis services.

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