Relying on advanced sequencing systems and cutting-edge technologies, Creative Proteomics provides reduced representative bisulfite sequencing (RRBS) services to global customers to help you comprehensively study embryonic development, aging mechanisms, and epigenetic mechanisms of disease development, and screen disease-related epigenetic marker sites, etc.
Reduced Representation Bisulfite Sequencing (RRBS) is an accurate, rapid, efficient and economical technology for DNA methylation research. Firstly, the fragments of CCGG sites on the genomic DNA are enriched by restriction enzyme digestion, and then by Bisulfite treatment and high-throughput sequencing, single-base resolution methylation sequencing in the CpG-enriched regions of the genome can be performed. This technology significantly improves the sequencing depth of CpG regions, and high-precision resolution can be obtained in CpG islands, promoter regions, and enhancer element regions. Therefore, we can study the methylation status of the covered regions in a targeted manner, making large-scale sample studies possible. It is widely used in large sample single base resolution methylation differential analysis and disease molecular marker development.
For reduced representation bisulfite sequencing (RRBS) of experimental samples, we followed the basic workflow shown below. At the same time, Creative Proteomics has developed a variety of new sample preparation technologies, and we will adjust the experimental methods and optimize the experimental conditions according to the different properties of the samples.
Type | Analyze content | |
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Advanced bioinformatics analysis | Alignment with reference genome
Methylation site (MS) information analysis
Genome-wide differential methylation site (DMS) analysis
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Personalized bioinformatics analysis | Personalized analysis requires contacting our technical engineers for evaluation. |
Creative Proteomics provides detailed reduced representation bisulfite sequencing (RRBS) and analysis services, please contact us for more information. We deserve your trust.
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